Search results for "SLC6A4 protein"

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Genome-wide association data provide further support for an association between 5-HTTLPR and major depressive disorder.

2013

Abstract Background Dysfunctions of serotonergic neurotransmission are supposed to be involved in the pathogenesis of psychiatric disorders such as major depressive disorder (MDD). The concentration of serotonin (5-hydroxytryptamine, 5-HT) in the synaptic cleft is essentially regulated by the 5-HT transporter (5-HTT). A length polymorphism repeat in the 5-HTT promoter region, termed 5-HTTLPR, has been commonly investigated for an association with psychiatric disorders. Methods Genotyping of the 5-HTTLPR is time-consuming and technically challenging. Recently, a two-SNP haplotype was identified that tags the 5-HTTLPR at r 2 =0.775. This allows extraction of 5-HTTLPR genotype information from…

AdultMaleLinkage disequilibriumSynaptic cleftGenotypeSingle-nucleotide polymorphismGenome-wide association studyPolymorphism Single NucleotideGermanygenetics [Haplotypes]mental disordersGenotypegenetics [Serotonin Plasma Membrane Transport Proteins]medicineHumansGenetic Predisposition to Diseaseddc:610GeneticsSerotonin Plasma Membrane Transport ProteinsDepressive Disorder MajorSLC6A4 protein humanHaplotypegenetics [Depressive Disorder Major]Middle Agedmedicine.diseasePsychiatry and Mental healthClinical PsychologyHaplotypes5-HTTLPRCase-Control Studiesgenetics [Polymorphism Single Nucleotide]Major depressive disorderFemalePsychologyClinical psychologyGenome-Wide Association StudyJournal of affective disorders
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